Set in the late Meiji period (Meiji period: 1868-1912).
Ten Fujioka's (Wakana Aoi) family has run a drug wholesale store for generations in Kyoto. She laughs a lot, but, due to her laugh, important business talk flounders. Her father, Gihee (Kenichi Endo), tells her not to laugh. One day, she meets a man Tokichi Kitamura (Tori Matsuzaka) who is chased by a bunch of men. Since then, Ten’s life changes.
Yukimasa Yugami (Tadanobu Asano) is a detective who chases after facts in cases. He will resort to illegal investigations and he uses his unique reasoning powers. His partner is rookie detective Torao Hanyu (Ryunosuke Kamiki).
It has been a year since the downfall of Hiruma Shigekatsu who had engaged in dirty hospital politics. Teito Medical University Hospital enters a new era with its first female hospital director. She touts “Patients first” and presses forward with big reforms to clean up the medical department. However, powerful persons in the hospital start working behind the scenes in an attempt to restore the unchecked powers and “black tower” which controlledthe hierarchical society to recapture their own “profits”. While Hiruma acts suspiciously, talented freelance surgeon Daimon Michiko fights the organisation head-on.
Ryo Kawakubo (Shota Matsuda) is a detective on a special team. When he was a child, he lived through a difficult time. He lived in poverty and his mother's negligence led to his younger sibling's death. His mother went missing and he has been looking for her.
Song Shi-On (Tae Min) is a smart guy. He graduated from a top medical school in the United States. He happily spends time with his girlfriend, but an experiment on his brain causes him to lose his memory.
Ryo Kawakubo and Song Shi-On have nothing in common, but work together on a special team formed by a secret organization of police officers. They try to solve difficult cases.
During the Sengoku period, the Ii family governs the Totomi region. Due to many past wars, there are no more male successors left to become a lord. Naotora Ii (Kou Shibasaki), the only daughter of the lord, now becomes a lord. She faces a difficult period. The constant love from her fiance, whom she became engaged with at a young age, helps her to keep moving forward.
Takashi Honami (Yutaka Takenouchi) is an associate professor in mathematics. He has a problem talking with others. His wife Nao (Mimura) becomes fed up with him and takes their child and leaves him. His boss at the university tells him to take a speech class, but Takashi Honami encounters trouble with his instructor Kyoko Ezaki (Kumiko Aso). A few days later, he meets Kyoko Ezaki again at an unexpected place.
Koichi Miyazawa (Koji Yakusho) runs a small, but longstanding company which makes tabi (traditional Japanese socks). He is the CEO of the fourth generation company with about 20 employees. Due to a decrease of demand for tabi, the company is struggling to keep afloat. Koichi Miyazawa thinks about launching a new product line. The new product is running shoes. For the company's surival, Koichi Miyazawa begins to develop running shoes using their accumulated knowledge for making tabi.
Nami Isayama (Haruka Ayase) met a man through a blind date and married him. She and her husband moved to a quiet, exclusive residential area. Nami is now a housewife and she decides to take cooking classes. She meets other housewives at the cooking class and receives tips from them, while becoming friends. Nami surmises that one of the housewives in her cooking class is the victim of domestic violence. Nami decides to save the victim by herself.
Tomoko Sato (Ryoko Shinohara) lives an ordinary life with her husband and son. As a child, her parents disappeared separately. She eventually had to drop out of high school, but Tomoko Sato was still able to live her life faithfully. She met her husband Kohei (Kei Tanaka) at work when she was a part-time employee.
Her husband has cycled through multiple jobs without ever securing a permanent position since they married. Tomoko works part-time to make ends meet, but she gets fired from her. She is in her 40's and a high school dropout. She is worried about finding another job. Tomoko Sato then watches TV and learns about a scandal concerning a city council member. She also learns that the pay for a city council member is high. She decides to run for the city council position for her family's happiness.