Set in the late Meiji period (Meiji period: 1868-1912).
Ten Fujioka's (Wakana Aoi) family has run a drug wholesale store for generations in Kyoto. She laughs a lot, but, due to her laugh, important business talk flounders. Her father, Gihee (Kenichi Endo), tells her not to laugh. One day, she meets a man Tokichi Kitamura (Tori Matsuzaka) who is chased by a bunch of men. Since then, Ten’s life changes.
Yukimasa Yugami (Tadanobu Asano) is a detective who chases after facts in cases. He will resort to illegal investigations and he uses his unique reasoning powers. His partner is rookie detective Torao Hanyu (Ryunosuke Kamiki).
It has been a year since the downfall of Hiruma Shigekatsu who had engaged in dirty hospital politics. Teito Medical University Hospital enters a new era with its first female hospital director. She touts “Patients first” and presses forward with big reforms to clean up the medical department. However, powerful persons in the hospital start working behind the scenes in an attempt to restore the unchecked powers and “black tower” which controlledthe hierarchical society to recapture their own “profits”. While Hiruma acts suspiciously, talented freelance surgeon Daimon Michiko fights the organisation head-on.
Mashiro Shibutani and her family live in Imizu, Toyama Prefecture. She spends her days by tending to her father’s bicycle store and taking care of her pet dog. She has a minor mental disability, but it doesn't effect her daily life. One day, she visits a shrine for her older brother's wedding. There, she meets photographer Keiichi Yui who came from Tokyo. Mashiro Shibutani accidentally presses the shutter button on Keiichi’s camera, which he left with her for a short while. Keiichi is fascinated by the pictures which Mashiro took on accident. Because of this, they get closer.
Kagerota (Takuro Ohno) is a young ninja. He is part of the Kiryu family. As a child, Kagerota's father left him at the age of 10. He was a legendary red nose ninja.
Kagerota travels to Edo for his first mission. He is to steal a gold fish from from a Daimyo Yashiki house. While leaving the house with the gold fish, Kagerota notices he is being followed by a fat cat. The cat has a red nose, just like his father.
Takeshi Yoroi (Junpei Mizobata) is a former street fighter, but he now works as a private investigator. Takeshi also possess a special suit made out of an augmented polymar. The suit transforms Takeshi Yoroi into Hurricane Polymar who has super strength, high-speed rotation and ability to transform into five different kinds of vehicles. He can only stay as Hurricane Polymar for up to 46 minutes and 1 second before reverting back. As Hurricane Polymar, Takeshi goes up against villains.
Ryo Kawakubo (Shota Matsuda) is a detective on a special team. When he was a child, he lived through a difficult time. He lived in poverty and his mother's negligence led to his younger sibling's death. His mother went missing and he has been looking for her.
Song Shi-On (Tae Min) is a smart guy. He graduated from a top medical school in the United States. He happily spends time with his girlfriend, but an experiment on his brain causes him to lose his memory.
Ryo Kawakubo and Song Shi-On have nothing in common, but work together on a special team formed by a secret organization of police officers. They try to solve difficult cases.
During the Sengoku period, the Ii family governs the Totomi region. Due to many past wars, there are no more male successors left to become a lord. Naotora Ii (Kou Shibasaki), the only daughter of the lord, now becomes a lord. She faces a difficult period. The constant love from her fiance, whom she became engaged with at a young age, helps her to keep moving forward.